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KMID : 0380620220540020241
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Korean Journal of Food Science and Technology
2022 Volume.54 No. 2 p.241 ~ p.246
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Inhibitory effects of tuberostemonine on Staphylococcus aureus biofilm
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Yum Su-Jin
Kim Seung-Min
Kwon Jun-Hyeok
Jeong Hee-Gon
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Abstract
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Antibiotic resistance is a serious problem to food safety as well as human healthcare. To avoid this, there are several approaches for a new class of antibiotic agents that target only production of virulence factors such as biofilm without bacterial growth defect. The objective of this study was to investigate the antibiofilm activity of tuberostemonine in Staphylococcus aureus. Tuberostemonine significantly reduced the biofilm formation (26.07-47.02%) in the crystal violet assay whereas there were no effect on S. aureus growth. The dispersion in preformed biofilm was also observed by confocal laser scanning microscopy (CLSM). Quantification real-time PCR revealed that the icaA and agrA expression having an important role in biofilm production of S. aureus were strongly affected with tuberostemonine. These results suggest that tuberostemonine has potential for controlling biofilm formation and dispersion by effect on virulence regulation of S. aureus.
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KEYWORD
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Staphylococcus aureus, tuberostemonine, biofilm, antibiofilm agent, food-borne pathogen
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